Post Doctoral, Mass Spectrometry Imaging

Description

As a Post-Doctoral Fellow to join the of Material and Analytical Sciences department, the incumbent will be a primary driver of fundamental independent research of novel therapeutic opportunities and technology, within the Development organization. Additionally, this role will be expected to present and publish research findings within internal and external scientific communities. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development, and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in several ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking, and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees.

Duties & Responsibilities

• The overall goal of this role will be to help develop mass spectrometry workflows from samples derived from animal tissue in order to gain better mechanistic understanding after animal dosing.  Specifically, we are looking to set up mass spectrometry imaging (MSI) workflows using a new Bruker timsTOF Flex with MALDI-2 high resolution mass spectrometer. Related to this effort you will also set up new proteomics-based workflows and be part of an interdisciplinary team to develop internal capability for using laser capture microdissection for mass spectrometry analysis.
• The qualified candidate should have demonstrated expertise in mass spectrometry imaging (MSI) analysis as well as experience developing chromatographic separations using HPLC or UPLC. Additionally, experience using mass spectrometry for structural elucidation and/or quantitation is strongly preferred.
• Additional requirements include a good understanding of molecular and cell biology and standard biochemical techniques such as electrophoresis and immunoprecipitation. Experience working with tissues and/or cell culture is desirable. This candidate will be part of a multidisciplinary research team with a focus on developing new tools/assays for enabling fundamental molecular and mechanistic understanding of development candidates. Excellent laboratory, communication and presentation skills are mandatory.
• Establishes an international reputation in your area of expertise with publications and conference participation at National and International events.
• Identifies and develops appropriate tools and methods to interpret and integrate scientific data.
• Complies with all applicable regulations, performing all work in a safe manner; maintains proper records in accordance with SOP´s and policies.
• Collaborates with leading academic institutions as well as other industrial partners.

Requirements

• Ph.D. degree in related discipline with no more than three (3) years of post-Doctoral experience. Candidates with academic training in biochemistry and/or mass spectrometry imaging are preferred.  Prior postdoctoral training is a plus.
• Experience in LC/MS and mass spectrometry imaging required.
• Demonstrated expertise in modern chromatographic techniques related to the characterization of large molecules such as oligonucleotides, peptides/proteins.
• Hands-on experience with chromatographic (e.g. HPLC) method development
• Experience in biophysical characterization techniques such as calorimetry, spectroscopy, and capillary electrophoresis for proteins and/or oligonucleotides is a plus
• In-depth knowledge in area of scientific expertise.
• Ability to think and plan strategically as well as tactically.
• Ability to demonstrate creativity and innovation in driving cutting-edge research with a strong publication record.
• Extensive experience in area of scientific expertise.
• Ability to think and plan strategically as well as tactically.
• Experience in data analysis.
• Hands-on experience with lab automation is a plus.
• Ability to independently conduct a research project and effectively communicate the results.
• Ability to optimize and develop assays/techniques, as well as leverage new technology opportunities to address scientific questions effectively.
• Critical and creative thinker, self-motivated to innovate and organize.
• Exceptional writing, presenting, and communicating skills.
• Ability to demonstrate creativity and innovation in driving cutting-edge research with a strong publication record.

Eligibility Requirements

• Must be legally authorized to work in the United States without restriction
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older