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Sr Principal/Principal Scientist, In Vivo Pharmacology - Immunology

Description

The In Vivo Sciences group within the Immunology & Respiratory (I&R) Discovery Research group is seeking a highly motivated, interactive, and team-oriented Principal Scientist/Sr. Principal Scientist to join our Ridgefield, CT Research team. The qualified candidate will lead research efforts focusing on in vivo studies to perform in vivo PK/PD and mechanism of action studies to support target validation, candidate selection and biomarker research discovery of novel therapeutic concepts developed to treat inflammatory and/or fibrotic conditions at Boehringer Ingelheim. Candidate must have strong analytical and problem-solving skills with proven track record of high research accountability and productivity both independently with minimal supervision and within a team setting in a matrix environment.

Duties & Responsibilities

  • Lead a laboratory dedicated to evaluating translational pharmacology relationships for I&R discovery projects, by making timely decisions and prioritization of resources across portfolio, acting quickly with new information and developing innovative plans to answer specific project aims. Actively engage in core project team meetings and governance forums, and to provide strategic input to individual projects and the department.
  • Develop, establish, coordinate, and conduct in vivo studies to provide PK/PD scientific leadership to project teams to support the selection of the right target, molecule as well as to explore mechanism of action and biomarker research, and work with DMPK and modeling scientists to help drive human dose estimation.
  • Be motivated to apply his/her skills to impact project needs and drive key innovative scientific concepts and enjoy working in a fast-paced dynamic team environment and proven ability to focus and deliver high quality data that support timely decisions for projects. 
  • Candidate must have strong analytical and problem-solving skills with proven track record of high research accountability and productivity both independently with minimal supervision and within a team setting in a matrix environment. 
  • Train and direct research scientists and ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. 
  • Ensure compliance with all required training, safety, regulatory, HR and intellectual property activities and corporate policies.

Requirements

Sr. Principal Scientist Requirements:

  • PhD in Immunology or related discipline with at least 7 years drug discovery experience in pharmaceutical industry or biotech or equivalent and, at least, 2 years in a group leadership role. 

 

Principal Scientist Requirements:

  • PhD in Immunology or related discipline with at least 5 years drug discovery experience in pharmaceutical industry or biotech and, at least, 2 years in a group leadership role. 

 

Requirements for both levels:

  • A demonstrated track record of independent research and peer-reviewed publications in areas of immunology or related research. Comprehensive knowledge of immunology and autoimmune diseases with deep understanding of mechanisms and pathways in immunological diseases and current treatment modalities. 
  • Strong understanding of mouse immunology, with exceptional in vivo experimental skills. Prior hands-on experience with mouse models of immunological diseases and developing novel in vivo models to assess the effects of novel therapeutic concepts are a must. Expertise in Inflammatory Bowel Disease, Dermatology and/or Fibrosis animal models is preferred. 
  • Strong knowledge of PK/PD and Pharmacology are essential. 
  • Knowledge of biomarker discovery, development, and analysis, including drug mechanism research and assay development/validation is highly recommended. 
  • Strong problem-solving skills and sound judgment to accelerate strategic and project decision-making. 
  • The ability to prioritize responsibility and be comfortable with changing direction and/or priorities.
  • Team player with exceptional verbal, presentation, and written communication skills, with the ability to propose, articulate, evaluate, and defend scientific ideas and data.
  • Ability to mentor, develop and lead a group of scientists to deliver high quality data to contribute to overall program goals. Be accountable for the effective performance of the individuals.

 

Compensation:

This position, Principal Scientist, offers a base salary typically between $135,000 and $232,000.  There is opportunity to consider higher compensation above this range based on business need, candidate experience and or skills.  The position may be eligible for a role specific variable or performance-based bonus and/or other compensation elements.  For an overview of our benefits please click here. 

Eligibility Requirements:

  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and post-offer physical (if required).
  • Must be 18 years of age or older.

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