Senior / Principal Scientist, Material and Analytical Sciences
Description
Boehringer Ingelheim is currently seeking a Senior or Principal Scientist to support our Material and Analytical Sciences team to join our Ridgefield, CT facility. This role is part of Boehringer Ingelheim’s Drug Substance–Drug Product Interface organization, driving innovation in small molecule development. The Principal Scientist/Sr. Scientist will lead efforts in solid-state chemistry and API engineering, focusing on phase-appropriate isolation processes and DS-DP co-processing technologies to ensure optimal material attributes—purity, crystal form, and physical properties. This position offers the opportunity to shape strategies for next-generation drug substance/drug product integration, collaborate across CMC Development and Operations, and implement cutting-edge solutions in manufacturing.
As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees.
Duties & Responsibilities
• Lead experimental design and hands-on execution for solid form, crystallization and isolation, and DS-DP co-processing development, applying QbD principles and appropriate engineering tools.
• Champion DS-DP Co-processing as a platform technology; drive implementation across Boehringer’s portfolio.
• Develop scalable crystallization and isolation processes, identifying CPPs and establishing robust control strategies.
• Conduct solid form screening (polymorphs, salts, co-crystals) and advanced characterization using XRD, DSC, TGA, DVS, Raman, and PAT tools.
• Collaborate with cross-functional CMC teams to ensure process robustness, scalability, and tech transfer to GMP manufacturing.
• Resolve scale-up challenges related to crystallization, particle engineering, and DS-DP integration; perform risk assessments and mitigation planning.
• Author technical reports, regulatory documentation, and contribute to IND/NDA filings.
• Serve as a scientific leader and mentor, fostering innovation and knowledge sharing within Material & Analytical Sciences.
• Stay ahead of emerging technologies (AI/ML, automation, continuous crystallization) and regulatory trends.
Requirements
Requirements for Both Levels:
• Strong expertise in solid-state chemistry, polymorphism, crystallization development, and Drug Substance (DS)-Drug Product (DP) interface.
• Proven ability to design processes, generate and analyze data, and interpret results independently.
• Hands-on development of cGMP isolation processes and scale-up principles.
• Excellent communication and collaboration skills; ability to influence in a matrix environment.
• Physical requirements: lift/carry up to 50 lbs.; respirator use may be required.
• Appropriate level of understanding of applicable regulations
Requirements for Senior Scientist:
• Ph.D. Degree in Chemical Engineering, Organic Chemistry, Pharmaceutical Science, Polymer Science, or related field or equivalent with experience in a related field
• Demonstrates a broad knowledge of field
• Appropriate level of understanding of applicable regulations
Requirements for Principal Scientist:
• Ph.D. Degree in Chemical Engineering, Organic Chemistry, Pharmaceutical Science, Polymer Science or related fields or equivalent with five plus (5+) years related experience in a related field
• At least 4 years post-graduation of pharmaceutical industry or relevant industrial experience in chemical engineering, process chemistry, physical chemistry or related fields.
• One (1) to three (3) years project management/leadership experience
• Has a proven track record of publication in peer-reviewed journals.
Desired Skills, Experience and Abilities:
• Experience in polymer science and DS-DP co-processing.
• Familiarity with predictive modeling tools, PAT, and CFD.
• Application of AI/ML for process optimization and digital development strategies.
Compensation Data
This position, Senior Scientist, MAS, offers a base salary typically between $140,000 and $222,000.00 USD. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here.
Eligibility Requirements
Must be legally authorized to work in the United States without restriction.
Must be willing to take a drug test and post-offer physical (if required)
Must be 18 years of age or older