Scientist III/IV, Biophysical Developability Assessments
Description
We currently seeking an innovative and ambitious Scientist III/IV, Biophysical Developability Assessments to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility.
The selected individual will be talented and experienced as a Scientist III/IV who will conduct a diverse set of biophysical assays related to the potential development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for designing, executing, analyzing, and interpreting assays and data that evaluate inherent protein attributes and physicochemical stability under a variety of conditions. The ideal candidate will be an analytical thinker with creative problem-solving skills; a quick learner who takes the initiative and manages workflows for several projects with enthusiasm and resourcefulness; an effective collaborator, working with different functional areas to enhance project knowledge.
As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.
****Candidate will be hired at level commensurate with experience and education***
Duties & Responsibilities
• Perform stage appropriate biophysical developability assessments, including biophysical screening of protein attributes on automated platforms, assessing solution behavior, stability, interpret and present findings to other Biotherapeutics Discovery colleagues.
• Develop novel analytical methodologies and evaluate new technologies to improve the overall developability strategy and enhance value.
• Contribute to broader research goals in areas related to biophysical chemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide biophysical characterization support for other scientists across Biotherapeutics Discovery; perform other tasks as assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.
Requirements
Scientist III Requirements:
• Master’s Degree from an accredited institution with three-plus (3+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with seven-plus (7+) years of experience in related scientific discipline or equivalent experience in related field
Scientist IV Requirements:
• Master’s Degree from an accredited institution with six-plus (6+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with ten-plus (10+) years of experience in related scientific discipline or equivalent experience in related field
Requirements for both levels:
• Extensive hands-on experience with chromatographic, spectroscopic, electrophoretic, calorimetric, or other advanced protein characterization techniques with several years of experience conducting biophysical techniques in the context of biotherapeutic discovery and/or development.
• Experience conducting protein biophysical techniques in the context of biotherapeutic discovery and/or development, including accelerated stability/forced degradation studies.
• Previous work in protein expression and purification.
• Experience with lab automation; in-depth knowledge (programming, troubleshooting) is preferred.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Strong grasp of physical chemical/thermodynamic principles underpinning protein structure and stability, biotherapeutic quality attributes, CMC requirements, and QbD principles.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.
Eligibility Requirements:
• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.
Compensation Data
This position offers a base salary typically between $75,000 and $147,000. The position may be eligible for a role specific variable or performance-based bonus and or other compensation elements. For an overview of our benefits please click here.