Scientist III/ IV, In Vivo - Cardiometabolic - Chronic Kidney Disease

Description

The Cardiovascular-Renal-Metabolic Diseases Research (CRMDR) team in Ridgefield, CT has delivered 7 first-in-class therapeutics into clinical development in the last decade in disease areas spanning Chronic Kidney Disease, Liver Cirrhosis, and Portal Hypertension. In the coming decade, our ambition will address the wider-reaching, interconnected cardio-renal-metabolic space. Innovation at Boehringer Ingelheim capitalizes on synergies with adjacent therapeutic areas, multi-disciplinary project teams, academic collaborations, and is strengthened by teaming up with CRMDR colleagues in Biberach, Germany.  People and culture are the drivers of success, and this engine is fueled by the intention to build enriching careers on the way as we deliver novel drugs.

The Translational Pharmacology group within Cardiovascular-Renal-Metabolic Diseases Research (CRMDR) is seeking a highly motivated, team-oriented Scientist III/IV to join our team in Ridgefield, CT. The qualified candidate will be involved in vivo research efforts focusing on techniques and studies that elucidate renal function using preclinical models spanning kidney, heart, and metabolic disease. This is a hands-on, lab-based position requiring candidates to have in-depth technical knowledge to lead science in a collaborative, multi-disciplinary research environment. Prior experience in drug discovery is desired.

The main responsibilities of the Scientist III/IV include independently developing, troubleshooting, and testing therapeutics in rodent animal models with minimal supervision, as well as investigation and implementation of new technologies to advance the field.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees.

Duties & Responsibilities

Scientist III:

• Design, execute, and analyze in vivo pharmacology studies in an independent and efficient manner, with minimal supervision
• Supports development and validation of rodent models for cardiometabolic diseases with emphasis on kidney diseases. Experience in cardiovascular rodent models is a plus
• Perform routine dosing (oral, IP, SC, IV), health monitoring, and sample collection in mice and rats
• Maintain compliance with IACUC protocols; maintain detailed experimental notes and documentation; treat data with integrity
• Communicate own work effectively orally and in writing; contribute to drafting protocols, procedures, and technical reports
• Collaborate cross-functionally in a team science setting with colleagues in histopathology, in vitro biology, and on project teams
• Initiates, designs, interprets accurately, troubleshoots and completes routine procedures independently and efficiently; Initiates, designs, interprets accurately, troubleshoots and completes non-routine and difficult procedures generally without supervision; Conducts exploratory experiments
• Proposes, gains support for and implements ideas from individual´s knowledge of science and technology and understanding of drug discovery process
• Proposes, evaluates and implements new technologies; Independently applies basic scientific principles, performs literature searches, attends scientific meetings, and keeps abreast of literature in own field
• Demonstrates a solid level of technical proficiency in field; Trains technicians and junior level scientists in this field
• Reports and treats data with a high level of integrity and ethics
• Complies with applicable regulations, performing all work in a safe manner; Maintains proper records in accordance with SOPs and policies

Scientist IV:

• Independently initiate, design, troubleshoot, and complete routine and non-routine experiments in an independent and efficient manner.
• Supports development and validation of rodent models for cardiometabolic diseases with emphasis on kidney diseases. Experience in cardiovascular rodent models is a plus
• Perform routine dosing (oral, IP, SC, IV), health monitoring, and sample collection in mice and rats
• Maintain compliance with IACUC protocols; maintain detailed experimental notes and documentation; treat data with integrity
• Propose, evaluate, and implement new experiments/technologies based on science as well as overall understanding of drug discovery/development process.
• Apply advanced scientific principles; stay current with literature and attend scientific meetings.
• Communicate and defend scientific work effectively in oral and written formats.
• Reports and treats data with a high level of integrity and ethics; Draft protocols, procedures, technical reports, and contribute to publications and presentations.
• Train and mentor technicians and junior scientists.
• Maintain compliance with safety and regulatory requirements; ensure accurate documentation per SOPs and policies.
• Participate in or lead cross-functional project teams.
• Act as a leader or delegate in the absence of a supervisor.

Requirements

For Both Scientist III and Scientist IV:

• This position requires moderate physical activity to complete work in the vivarium and laboratory. This includes but is not limited to standing for extended durations (>2 hours), working under a biosafety hood/cabinet for extended durations (>2 hours), bending, lifting (up to 20 lbs), squatting, pushing/pulling, and reaching. This is in addition to handling and restraint of small laboratory animals (rats, mice; >50 at a time) daily and often within a specified timeframe.
• This position requires use of personal protective equipment (PPE) including respiratory, eye, hand, and foot protection.
• Willingness to support weekend work as needed.

Scientist III:

• Master´s Degree with 3+ years experience in a related scientific discipline or Bachelor´s Degree with 7+ years experience in a related field or equivalent experience in a related field. Pharmaceutical, biotechnology company or CRO experience is highly desirable.
• Proficient in rodent handling, including oral, IP, SC, and IV dosing; blood sampling; health monitoring; and tissue/sample collection.
• Demonstrated scientific curiosity with strong problem-solving and troubleshooting skills.
• Effective written and verbal communication skills and ability to work collaboratively in a team-based research environment.
• Advanced training in the area of technical expertise
• Propose new experimental designs, Conduct probing experiments
• Plan and conduct laboratory experiments and evaluate and interpret data
• Provide training and guidance to laboratory personnel
• Prepare technical reports, publications and oral presentations
• Act as a leader in absence of supervisor
• Appropriate level of understanding of applicable regulations

Scientist IV:

• Master’s degree with 6+ years of experience, or Bachelor’s degree with 10+ years of experience in a related field or equivalent experience in a related field. Pharmaceutical, biotechnology company or CRO experience is highly desirable.
• Extensive hands-on expertise in rodent handling, including oral, IP, SC, and IV dosing; blood sampling; health monitoring; and comprehensive tissue and sample collection.
• Advanced proficiency in in vivo pharmacology techniques, with primary emphasis on renal and cardio-renal disease research, including chronic kidney disease (CKD).
• Experience with metabolism cages and telemetry system
• Demonstrated ability to independently design, execute, troubleshoot, and optimize complex in vivo pharmacology models
• Proven expertise in experimental design, data interpretation, and rigorous scientific problem-solving to support project and portfolio advancement.
• Strong written and verbal communication skills, with experience preparing technical reports, scientific publications, and internal/external presentations.
• Demonstrated ability to train, mentor, and scientifically guide laboratory personnel, fostering technical excellence and scientific curiosity within the team.
• Solid understanding of applicable regulations (e.g., animal welfare and research compliance) and the ability to operate in a leadership capacity within cross-functional research teams.

Desired Skills, Experience and Abilities

Scientist III:

• Demonstrated expertise in in vivo pharmacology with a strong emphasis on chronic kidney disease (CKD) and renal biology; experience with cardiovascular disease models is a plus.
• Hands-on experience with renal disease and surgical models (e.g., 5/6 nephrectomy, unilateral nephrectomy) is a plus.
• Experience with metabolism cages and telemetry systems is a plus.
• Proven ability to develop, execute, troubleshoot, and optimize in vivo pharmacology models; experience with dosing test articles and renal-related disease areas (e.g., primary glomerulonephritis or cardio-renal metabolism) is a plus.
• Invasive hemodynamics experience is a plus.

Scientist IV:

• Strong experience with renal surgical disease models, including but not limited to 5/6 nephrectomy and unilateral nephrectomy, is highly preferred.
• experience with dosing test articles and renal disease areas such as primary glomerulonephritis and/or cardio-renal metabolism is highly preferred.
• Invasive hemodynamics experience is a plus.

Compensation:

The base salary range for this position, Scientist III, is $90,000.00 to $147,000.00.  The position may be eligible for a role specific discretionary bonus, relocation, and/or other compensation elements.  We continuously review market data and may adjust salary ranges as needed in the future.  Actual compensation will be based on job-related factors such as skills, experience, and qualifications, and other factors permitted by law. For an overview of our benefits please click here.  

Eligibility Requirements:

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older