Scientist - Oligonucleotide Synthesis Expert, Medicinal Chemistry

The Position

Join us in shaping the future of drug discovery.

In this exciting role, you will actively drive the establishment and advancement of oligonucleotide-based drug discovery capabilities within Medicinal Chemistry, leveraging your expertise in oligonucleotide synthesis to create innovative therapeutic solutions. Our mission is to deliver high-quality, first-in-class drug candidates within competitive timelines while advancing new therapeutic concepts and modalities for targets of interest. Guided by a passion for excellence in drug design, synthesis, lead identification, and optimization, you will collaborate with world-class scientists and make a meaningful impact on the development of next-generation medicines.

Ready to make a difference? Apply now and help transform groundbreaking science into life-changing therapies.

Tasks & responsibilities

• In your new role, you will drive the technical execution of siRNA projects.
• You will execute solid-phase oligonucleotide synthesis at research to mid-scale using RNA synthesizers, applying both routine and next-generation phosphoramidite chemistries.
• Furthermore, you will plan, optimize and trouble-shoot methods to improve coupling, capping, deprotection, cleavage, yield, purity and scalability, and oligonucleotide conjugation chemistries.
• You will coordinate and perform purification, desalting and analytical characterization of oligonucleotides.
• Moreover, you will operate, maintain and troubleshoot critical laboratory instrumentation, and take accountability for the oligonucleotide synthesis facility.
• You will train and coordinate Laboratory Scientists, providing technical guidance and fostering knowledge sharing across the team.
• Finally, you will document results with a high level of accuracy and reproducibility, contribute to patent applications, and provide technical expertise as a hands-on point of contact for synthesis and purification questions in project teams..

Requirements

• Completed vocational training or Master’s or Bachelor’s degree in a relevant scientific discipline with extensive hands-on experience in oligonucleotide synthesis
• Strong practical expertise in solid-phase synthesis, deprotection, purification and analytical characterization of oligonucleotides including method development and optimization
• Sound knowledge of oligonucleotide conjugates, linker chemistry, and bioconjugation approaches
• Hands-on experience with laboratory instrumentation used in oligonucleotide synthesis and analysis; experience in setting up or managing an oligonucleotide laboratory is highly desirable
• Interest in innovative RNA therapeutics and modern drug discovery.
• Independent, structured and reliable working style.
• Collaborative and team-oriented mindset with excellent interpersonal and communication skills
• Fluency in written and spoken English, coupled with a willingness to acquire basic German language skills

Start date: ASAP

As part of our commitment to transparency and fairness, salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package. Applications from persons with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process. 

Ready to contact us? 

If you have any questions about the job posting or process - please contact our HR Direct Team, Tel: +49 (0) 6132 77-3330 or via mail: hr.de@boehringer-ingelheim.com

Recruitment process:
Step 1: Online application - The job posting is presumably online until September 7th,2026. We reserve the right to take the posting offline beforehand.
Step 2: Virtual meeting in the period from beginning till mid of September
Step 3: On-site interviews end of September

Please submit your application documents in English.