Senior Scientist-Peptide Synthesis

About Human Pharmaceutical Business
With global presence, Boehringer Ingelheim has industry-leading expertise in medicine research and development. We are constantly developing the next generation of medical breakthroughs and successfully delivering innovations to meet the medical needs of the patients we serve in the following key areas of interest: cardiovascular, respiratory, metabolic diseases, immunology, oncology and central nervous system. In the future, we will accelerate the launch of more than 10 innovative medicines to meet the demand of Chinese patients. 

Position Summary
This role focuses on late-stage peptide process development with an emphasis on process robustness, consistency, and cost efficiency. The successful candidate will drive process optimization from development through scale-up and commercialization, ensuring stable, reproducible, and economically viable manufacturing processes.

Key Responsibilities
- Lead late-stage process development and optimization for peptide products, with a focus on SPPS processes
- Improve process robustness, batch-to-batch consistency, and define proven acceptable ranges
- Optimize raw material usage, cycle times, and process efficiency to reduce manufacturing cost
- Identify and control critical process parameters (CPPs) and critical quality attributes (CQAs)
- Support and lead technology transfer to pilot plant and commercial manufacturing sites
- Collaborate with analytical, quality, and manufacturing teams to resolve scale-up issues
- Conduct root cause analysis, deviation investigations, and continuous improvement (CI) initiatives
- Develop platform approaches for peptide synthesis and purification
- Prepare technical reports, process documentation, and regulatory support documents

Qualifications
- Master's or Ph.D. in Chemistry, Pharmaceutical Sciences, or related field
- 3+ years of experience in peptide process development or optimization
- Hands-on experience in process scale-up from lab to pilot or commercial manufacturing
- Strong knowledge of solid-phase peptide synthesis (SPPS)
- Proven experience in cost reduction and process efficiency improvement
Technical Skills
- Deep understanding of peptide synthesis mechanisms and impurity control
- Experience with analytical techniques such as HPLC and LC-MS
- Familiarity with Design of Experiments (DoE) methodologies
- Knowledge of purification techniques (Prep-HPLC, crystallization, membrane processes)
- Understanding of GMP requirements for process development and scale-up
Core Competencies
- Strong data analysis and problem-solving skills
- Effective cross-functional communication and collaboration
- Engineering mindset with focus on scalability, reproducibility, and cost
- Results-driven with focus on quality and efficiency balance
Preferred Qualifications
- Experience with commercial peptide or API manufacturing
- Experience in process validation and regulatory submissions
- Exposure to continuous manufacturing or automation technologies