Scientist - Enzyme Scientist

About Human Pharmaceutical Business
With global presence, Boehringer Ingelheim has industry-leading expertise in medicine research and development. We are constantly developing the next generation of medical breakthroughs and successfully delivering innovations to meet the medical needs of the patients we serve in the following key areas of interest: cardiovascular, respiratory, metabolic diseases, immunology, oncology and central nervous system. In the future, we will accelerate the launch of more than 10 innovative medicines to meet the demand of Chinese patients.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Job Description

• Lead enzyme engineering efforts within cross-functional teams, ensuring alignment of strategies with discovery and development goals.
• Conduct comprehensive literature reviews and data collection on enzyme genes, propose actionable solutions, and contribute to their effective implementation.
• Maintain up-to-date knowledge of emerging technologies and actively collaborate with academic and industry partners.
• Oversee enzyme production and process at pilot and commercial scales, facilitate technology transfer processes, and collaborate with Contract Development and Manufacturing Organizations (CDMOs) as required.
• Work alongside a highly motivated team in a fast-paced, mission-driven work environment.

Duties & Responsibilities

• Design enzymatic pathways for target products by enzyme mining, developing enzyme libraries, managing high-throughput screening, and optimizing enzyme through engineering methods.
• Enhance and optimize workflows for the identification of enzyme variants with improved activity, stability, and specificity tailored to specific organic reaction.
• Utilize protein structure modeling, molecular docking, molecular dynamic simulation, and computer-aided design to develop, optimize and modify enzymes.
• Analyze complex datasets, prepare comprehensive reports, effectively communicate findings to internal and external stakeholders and apply  intellectual property rights principles.
• Comply with applicable regulations and performs all work in a safe manner. Maintain proper records in accordance with SOPs and policies. Demonstrate corporate and CoC culture (Learning agility, value through innovation, can do attitude, craft-man spirits, et.al).

Requirements:

• PhD with 2+ years (or MSc with 4+ years or Bachelor's degree with 7+ years) in synthetic biology, enzyme engineering, biochemistry, genetic engineering, metabolic engineering, or related disciplines.
• Exhibit proven experience in synthetic biology industry, including the successfully commercialization of at least one product.
• Demonstrate expertise in gene cloning and molecular biology techniques with a strong familiarity with E. Coli expression systems and advanced methodologies for enzyme modification and directed evolution experiments.
• Proven experience in collaborating with cross-functional teams to ensure that enzymatic process development aligns seamlessly with project timelines and objectives.
• Possess comprehensive knowledge of protein analytical techniques, including SDS-PAGE, Western blot, HPLC, Octet/Biacore, mass spectrometry (MS), and isoelectric focusing (IEF).
• Excellent communication and teamwork abilities for cross-functional collaboration.

Even better:

• Extensive experience in artificial intelligence (AI), machine learning (ML), bioinformatics, and other innovative digital tools, contributing to the advancement and future development of biocatalysis.
• Demonstrated expertise in operating and integrating automated instruments, including qPRC, next-generation sequence (NGS), and flow cytometry. 

Our Culture:

Innovative medicines for people and animals have for more than 130 years been what the research-driven pharmaceutical company Boehringer Ingelheim stands for. Boehringer Ingelheim is one of the pharmaceutical industry’s top 20 companies and to this day remains family owned. Day by day, our employees create value through innovation for the three business areas human pharmaceuticals, animal health and biopharmaceutical contract manufacturing.

Boehringer Ingelheim operates globally with approximately 50,000 employees. Since we are privately held, we have ability to take an innovative, long-term view. Our focus is on scientific discoveries and the introduction of truly novel medicines that improve lives and provide valuable services and support to patients and their families. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture allows and drives us to maintain one of the highest levels of excellence in our industry.

CoC (Center of Chemistry) is a highly competitive team with strong scientific competence, can-do attitude, and agility enabling high-quality deliveries.